| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1388825 | Carbohydrate Research | 2008 | 10 Pages |
Abstract
An efficient route to the trans-fused tetrahydrooxepin corresponding to the E ring of ciguatoxin was developed. Wide screening of allylation reactions of sulfur or fluoro-substituted tetrahydrooxepin revealed that the optimum method for obtaining the β-allylation product selectively was the use of a combination of allyltrimethylsilane and TiCl4 with 6-fluoro-7-hydroxytetrahydrooxepin.
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Authors
Shoji Kobayashi, Makiko Hori, Masahiro Hirama,