| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1388864 | Carbohydrate Research | 2007 | 7 Pages |
Abstract
A total synthesis of the 12-membered ring natural macrolide, sporiolide B, was achieved from d-glucal in 17 steps with 4.8% overall yield. The required stereochemical configuration at C-3 and C-5 in sporiolide B was easily introduced by applying a Mitsunobu reaction on the chiral template d-glucal. Yamaguchi esterification and ring closing metathesis greatly improved the access to the target compound.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qi Chen, Yuguo Du,