| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1389001 | Carbohydrate Research | 2009 | 7 Pages |
Abstract
Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claudia Sorbi, Massimo Bergamin, Susanna Bosi, Francesca Dinon, Vincent Aroulmoji, Riaz Khan, Erminio Murano, Stefano Norbedo,