Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1389029 | Carbohydrate Research | 2007 | 5 Pages |
Abstract
The investigation of drug metabolism requires substantial amount of metabolites. Isolation from urine is tedious, therefore, the material obtained by synthesis is preferred. Substantial amounts of three tentative drug metabolites, phenolic glucuronides, have been prepared using easily available glycosyl donors. The final products [3(2-N-methyl-N-isopropylaminoethoxy)phenyl] β-d-glucopyranosiduronic acid, 4-amino-3,5-dimethylphenyl β-d-glucopyranosiduronic acid and [2(S)-propanoyl-6-O-naphthyl] β-d-glucopyranuronic acid are useful as, for example, reference material in metabolite investigations.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carl Johan Arewång, Martina Lahmann, Stefan Oscarson, Anna-Karin Tidén,