| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1389074 | Carbohydrate Research | 2011 | 5 Pages |
Abstract
The common route to link quinolinium and pyridinium fluorophores to biomolecules via bromoacetic acid has failed in labeling the disaccharide trehalose with N-methyl-6-oxyquinolinium betaine: the unexpected, extremely high instability of the N-carboxymethyl ester was overcome by direct N-alkylation of the quinoline derivative with trehalose triflate.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Facile preparation of N-methyl-6-oxyquinolinium betaine labeled trehalose. ► N-Carboxymethyl ester of trehalose rapidly hydrolyses in neutral protic media. ► Fluorescently labeled trehalose for studying solvation dynamics.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Falko Berndt, Mohsen Sajadi, Nikolaus P. Ernsting, Rainer Mahrwald,