Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1389233 | Carbohydrate Research | 2007 | 10 Pages |
Abstract
The synthesis of three novel glycosyl donors presenting the same scaffold as α-l-arabinofuranose but modified at the C-2 or C-5 positions has been achieved. Furthermore, chemoenzymatic syntheses using the α-l-arabinofuranosidase AbfD3 and these unnatural furanosides were investigated. The use of the novel p-nitrophenyl furanoside donors revealed that AbfD3 can perform transglycosylation with the C-5 deoxygenated donor but not with the C-2 modified one. These results emphasize the vital role for OH-2 in AbfD3 substrate recognition.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gérald Lopez, Caroline Nugier-Chauvin, Caroline Rémond, Michael O’Donohue,