| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1389371 | Carbohydrate Research | 2010 | 5 Pages |
Abstract
A series of novel glycosyl thiazol-2-imines (3a–g) have been synthesized regioselectively in good yields from the hydrolysis of thiazol-2(3H)-imine-linked glycoconjugates. The glycosyl thiazol-2-imines were evaluated for their antitumor activity against Hela (cervical carcinoma), HCT-8 (colon carcinoma) and Bel-7402 (liver carcinoma). Among the compounds screened, 1-benzoyl-4-(4-nitrophenyl)-3-β-d-glucopyranosyl-thiazol-2(3H)-imine (3c) was found to be the most active compound against HCT-8.
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Related Topics
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Organic Chemistry
Authors
Qing Zhao, Chao Shen, Hui Zheng, Jinchao Zhang, Pengfei Zhang,