| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1389382 | Carbohydrate Research | 2006 | 5 Pages |
Abstract
The natural cytotoxic marine compound, jaspine B, is stereoselectively synthesized from d-xylose in 11 linear steps with a 23.9% overall yield. The key step in the synthesis involves an iodine-induced debenzylation of a primary alcohol and the subsequent 2,5-cyclization to fit the required configuration of jaspine B. A preliminary bioassay shows strong inhibition activities against human MDA231, Hela, and CNE cell lines, indicating potential usage in various cancer treatments.
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Related Topics
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Authors
Jun Liu, Yuguo Du, Xiaomin Dong, Shucong Meng, Junjun Xiao, Lijian Cheng,