Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1389463 | Carbohydrate Research | 2009 | 7 Pages |
Abstract
Efficient sialylations using N-glycolylneuraminic acid (Neu5Gc) phosphite donors having an acetyl or benzyl group on the glycolyl moiety are described in the synthesis of Neu5Gc-containing glycans. Both phosphite donors 1 and 2 were readily coupled with primary and secondary acceptor alcohols in propionitrile at −78 °C to provide the desired glycosides with good α-selectivities.
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Authors
Shinya Hanashima, Taku Tomiya, Daichi Ishikawa, Shoji Akai, Ken-ichi Sato,