Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1389636 | Carbohydrate Research | 2008 | 7 Pages |
Abstract
We report a simple, efficient, and mild method for the synthesis of ω-aminoalkyl 2-deoxy-d-arabino/lyxo-hexopyranoside and 2,3-dideoxy-α-d-erythro-hexopyranoside. The total synthesis is accomplished in two sequential reactions. The first step consists of an addition reaction of N-(ω-hydroxyalkyl)phthalimide and N-(ω-hydroxyalkyl)succinimide to peracetylated d-glycals, which is promoted by triphenylphosphine hydrobromide or borontrifluoride/diethyl etherate. The second step involves reacting the appropriate glycoside with methylamine.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anna W. Pierwocha, Krzysztof Walczak,