Synthesis of modified D-mannose core derivatives and their impact on GH38 α-mannosidases

- New D-lyxose and D-mannose derived models with five- and modified six-member core.
- Triazole and sulfone derivatives for inhibition of the GH family 38 α-mannosidases.
- None of the compounds affected dLMII.
- Two compounds inhibited dGMIIb albeit weakly (IC50 at mM level).
- Contrary to sulfones, all triazoles worked as jack bean α-mannosidase inhibitors.