Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage

•Anomeric galactolipid mixtures have synergistic cytotoxic effect for MM.•A mixture produces more apoptotic MM cells than either anomer alone.•The mixture also induces PARP cleavage and DNA damage.

This study describes an interesting observation that the mixture of anomeric galactolipids has synergistic effects on the growth inhibition of human multiple myeloma (MM) cells. We determine that the equivalent mixture of a pair of α- and β-galactolipids with a 14-carbon lipid chain can cause stronger poly ADP-ribose polymerase cleavage and DNA damage, producing more late apoptotic MM cells, than either anomer alone.

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