| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1390248 | Carbohydrate Research | 2013 | 5 Pages |
•Two new steroidal saponins were isolated from the roots of Cynanchum paniculatum.•Structures of the new saponins were elucidated by spectroscopic analyses.•Cytotoxicity of the compounds was evaluated against four cancer cell lines in vitro.
Two new steroidal saponins, cynanside A (1) and B (2) were isolated together with three known compounds (3–5) from the roots of Cynanchum paniculatum (Bunge) Kitag. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses, including extensive 2D NMR and acid hydrolysis. We evaluated the cytotoxicity of isolates (1–5) against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the SRB bioassay. Compounds 1 and 2 showed selective cytotoxicity against SK-MEL-2 cells with IC50 values of 26.55 and 17.36 μM, respectively.
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