Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1390418 | Carbohydrate Research | 2011 | 13 Pages |
Abstract
The total chemical synthesis of a Forssman antigen analog is described. The pentasaccharide contains a functionalized tether which should facilitate future conjugation with immunogenic proteins. We found that the total synthesis can be efficiently achieved by following a convergent 2+3 strategy, and using N-Troc protected GalNAc thioglycoside as a donor.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jianhao Feng, Rachel Hevey, Chang-Chun Ling,