Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1390420 | Carbohydrate Research | 2011 | 6 Pages |
Abstract
New highly soluble β-aminoalcohol β-cyclodextrin (β-CD) derivatives have been synthesized via nucleophilic epoxide opening reactions with mono-6-amino mono-6-deoxy-permethyl-β-CD and mono-6-amino mono-6-deoxy-β-CD. The binding properties of the β-CD were enhanced by linking aminoalcohol subunits which caused its solubility to improve markedly. The reaction conditions were optimised using microwave irradiation giving moderate-to-good yields with a series of epoxides. A regioselective epoxide opening reaction was observed in the reaction with styrene oxide while the stereoselectivity was strictly dependent on substrate structure.
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Related Topics
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Organic Chemistry
Authors
K. Martina, M. Caporaso, S. Tagliapietra, G. Heropoulos, O. Rosati, G. Cravotto,