| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1390469 | Carbohydrate Research | 2011 | 9 Pages |
(1→3)-β-d-Glucans are well-established natural biological immunomodulators. However, problems inherited with the natural origin of these polysaccharides bring about significant setbacks, including batch-to-batch heterogeneity and significant differences based on the source and isolation techniques. In this study, we tried to overcome these problems by preparation of a quantitatively new set of oligo-(1→3)-β-d-glucan-based synthetic immunomodulators. Some of these non-natural oligosaccharides showed biological activities, such as stimulation of phagocytosis, modulation of gene expression, and anti-cancer activity, which were superior to natural glucans.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► We prepared four different glucan-based synthetic immunomodulators. ► These oligosaccharides strongly stimulate phagocytosis. ► All of them modulate gene expression and inhibit cancer. ► Their immunological activities are superior to natural glucans.
