| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1390514 | Carbohydrate Research | 2011 | 4 Pages |
Trehalose dihydrate is a safe, naturally occurring disaccharide used as a food ingredient and pharmaceutical excipient. It has been reported that room temperature milling does not lead to the formation of amorphous trehalose dihydrate. This paper reports the behaviour of trehalose dihydrate upon milling at cryogenic temperatures as studied by DSC, TGA, XRPD and Raman spectroscopy. We have demonstrated that the crystal to glass transformation for trehalose dihydrate is possible using cryogenic milling. This is the first reported example of cryogenic milling (a mild and widely applicable technique) applied to generating amorphous hydrates.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► Cryogenic milling of sugar hydrate. ► First example of amorphous trehalose dihydrate by cryogenic milling. ► Crystal to amorphous transformation of trehalose dihydrate studied by DSC, TGA, XRPD and Raman spectroscopy.
