| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1390641 | Carbohydrate Research | 2010 | 7 Pages |
Abstract
The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rémy Dureau, Florence Robert-Gangneux, Jean-Pierre Gangneux, Caroline Nugier-Chauvin, Laurent Legentil, Richard Daniellou, Vincent Ferrières,