Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1390690 | Carbohydrate Research | 2009 | 7 Pages |
Abstract
A novel approach to synthesize glucose-based 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazoles with the assistance of microwave irradiation was developed. The effects of different catalysts on the heterocyclization process were investigated, and the reaction conditions were optimized, with NaOAc emerging as the catalyst of choice. Under the optimized conditions, a series of novel 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazole derivatives 4 and 5 were successfully synthesized from hydrazones 2 and 3. The absolute configurations of hydrazones 2, 3 and oxadiazoles 4, 5 were confirmed by NMR spectroscopic data. The ratio of the isomers 4 and 5 was ∼1:1.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lin-Na Wang, Dong Han, Fei-Fei Xu, Xiang-Bao Meng, Zhong-Jun Li,