RETRACTED: N-Acetyl-d-glucosamine substituted calix[4]arenes as stimulators of NK cell-mediated antitumor immune response

The above paper describes synthesis of a series of substituted calixarenes, which were fully characterized and their binding to the human receptor CD69 and rat receptor NKR-P1and respective interactions. Unfortunately, we have learned recently that the author responsible for the immunological experiments - Prof. Karel Bezouška - has been fabricating the results and also illegally manipulating with experimental material in collaborating laboratories. Based on the findings of the joint ethical committee of the Institute of Microbiology, Acad. Sci. of the Czech Republic, and Charles University in Prague and based on the extensive re-evaluation experiments [1, 2] done by us we consider all the data on the binding of ligands to the CD69 and NKR-P1 receptors erroneous and, therefore, we retract the above publication.We would like to state that all synthetic work in this paper, namely the synthesis of compounds 1, 1a, 3, 3a, and 4, including all spectral characteristics (NMR, MS) was not affected by the misconduct and, therefore, remains valid.We would like to apologize to all affected parties.V. Kren, Corresponding author[1] D. Rozbeský , J. Krejzová , K. Krenek, J. Prchal, R. Hrabal, M. Kožišek, L. Weignerová , M. Fiore, P. Dumy, O. Renaudet, V. Kren: Reevaluation of Binding Properties of Recombinant Lymphocyte Receptors NKR-P1A and CD69 to Chemically Synthesized Glycans and Peptides. Int. J. Mol. Sci.15, 1271-1283 (2014).[2] V. Grobá rová , V. Benson, D. Rozbesky, P. Novak, J. Cerny: Re-evaluation of the involvement of NK cells and C-type lectin-like NK-receptors in modulation of immune responses by multivalentGlcNAc-terminated oligosaccharides. Immunol. Lett.156, 110-117 (2013).

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