Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1390837 | Carbohydrate Research | 2007 | 7 Pages |
Abstract
1H-[1,2,3]-Triazol-1-yl mannosides have been synthesized as inhibitors for the β-galactoside-binding family of galectin proteins. Easier synthetic access to C1 in mannose, as compared to C3 in galactose, for attachment of affinity-enhancing triazoles rendered a synthetic advantage. The best mannose-derived inhibitor for galectin-9N, 4-benzylaminocarbonyl-1H-[1,2,3]-triazol-1-yl β-d-mannopyranoside, had a Kd value of 540 μM, which compares favorably with its galactoside counterpart (Kd = 670 μM) and with LacNAc (Kd = 500 μM).
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Related Topics
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Authors
Johan Tejler, Fredrik Skogman, Hakon Leffler, Ulf J. Nilsson,