Synthesis of complex-type glycans derived from parasitic helminths

Chemical syntheses of complex-type glycans derived from the eggs of parasitic helminths, Schistosoma mansoni and Schistosoma japonicum were achieved. In addition, their analogs, which lack xylose and/or fucose residue(s), are described. These branched sugar chains were synthesized regio- and stereoselectively by using β-mannosylation, desilylation under high-pressure and glycosylation in frozen solvent as key transformations.

Graphical abstractNovel glycoprotein oligosaccharides derived from Schistosoma mansoni as well as their congeners were synthesized systematically.Figure optionsDownload full-size imageDownload as PowerPoint slide