| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1390881 | Carbohydrate Research | 2007 | 8 Pages |
Abstract
Functionalized carbohydrate-centered glycoclusters formed the starting material for the synthesis of tagged oligosaccharide and glycoconjugate mimetics, which were obtained by thiourea-bridging, peptide coupling and in particular squaric diester-mediated coupling. The latter method could also be utilized to provide new multivalent glycoconjugates, which were tested for their anti-adhesive properties in an ELISA with Escherichia coli bacteria.
Graphical abstractCarbohydrate-centered glycoclusters were fluorescence-labeled, functionalized to amphiphilic conjugates and multimerized using squaric acid. Inhibitory potencies in bacterial adhesion were measured.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Oliver Sperling, Michael Dubber, Thisbe K. Lindhorst,