Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1390971 | Carbohydrate Research | 2006 | 17 Pages |
Abstract
A short and highly efficient route to various C-4 substituted sugar lactones has been developed. The key to the overall transformation is the sequential osmium-catalyzed dihydroxylation reaction of substituted 2,4-dienoates and an allylic substitution at the C-4 position. When the Sharpless AD-mix procedure is used in a matched sense for the second dihydroxylation reaction, it results in an exceedingly diastereo- and enantioselective synthesis of several C-4-substituted sugars.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Md. Moinuddin Ahmed, George A. O’Doherty,