Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1390972 | Carbohydrate Research | 2006 | 11 Pages |
Abstract
A synthetic study on α-(1â4) and α-(1â8)-fucosylation of sialic acid is reported, with the ultimate aim being the total assembly of the glycan portion of HPG-series gangliosides. In both types of fucosylations, the combination of a phenylthio fucosyl donor and a 1,5-lactamized acceptor provided high-yielding glycosylations to afford α-fucosyl-sialic acid sequences. The obtained α-Fucp-(1â8)-NeupNAc glycan having a 1,5-lactam bridge has been successfully transformed into the corresponding glycosyl donor.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiromune Ando, Hiroyo Shimizu, Yukari Katano, Yusuke Koike, Sachiko Koizumi, Hideharu Ishida, Makoto Kiso,