Article ID Journal Published Year Pages File Type
1390980 Carbohydrate Research 2006 15 Pages PDF
Abstract

The synthesis of a set of various sulfoforms and/or phosphoforms as 7-methoxy-2-naphthyl glycosides of β-d-Xylp, β-d-Galp-(1→4)-β-d-Xylp, and β-d-Galp-(1→3)-β-d-Galp-(1→4)-β-d-Xylp, structures encountered in the common carbohydrate–protein linkage region of proteoglycans, is reported for the first time. These molecules will serve as probes for systematic studies of the substrate specificity of the glycosyltransferases involved in the early steps of the biosynthesis of proteoglycans. A straightforward divergent preparation was achieved using key intermediates, which were designed as common precursors.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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