Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1390980 | Carbohydrate Research | 2006 | 15 Pages |
Abstract
The synthesis of a set of various sulfoforms and/or phosphoforms as 7-methoxy-2-naphthyl glycosides of β-d-Xylp, β-d-Galp-(1→4)-β-d-Xylp, and β-d-Galp-(1→3)-β-d-Galp-(1→4)-β-d-Xylp, structures encountered in the common carbohydrate–protein linkage region of proteoglycans, is reported for the first time. These molecules will serve as probes for systematic studies of the substrate specificity of the glycosyltransferases involved in the early steps of the biosynthesis of proteoglycans. A straightforward divergent preparation was achieved using key intermediates, which were designed as common precursors.
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Related Topics
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Authors
Jean-Claude Jacquinet,