Multivalent glycomimetics: synthesis of nonavalent mannoside clusters with variation of spacer properties

Oligosaccharide mimetics are important tools in the glycosciences. In this work, we have employed spaced glycodendrons for the synthesis of oligomannoside mimetics. Starting from a number of trivalent, branched molecular wedges, the preparation of nonavalent cluster mannosides was accomplished, which were varied with regard to the chemical characteristics of their spacer moieties and spacer lengths. For ligation of the various trivalent dendrons to the nonavalent target molecules peptide coupling was employed.

Graphical abstractA modular approach to oligomannoside mimetics was exemplified with the synthesis of nonavalent glycodendrons with flexible spacer lengths.Figure optionsDownload full-size imageDownload as PowerPoint slide