| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1391634 | Chemistry & Biology | 2009 | 8 Pages |
Abstract
SummaryAs glycosyltransferases found in nature often show distinct substrate specificity, glycosyltransferase engineering is an important research field. In this work, we were able to introduce an activity into a glycosyltransferase involved in natural product (landomycin E) biosynthesis. This was achieved by recognizing hot spot amino acids in glycosyltransferases which are strongly involved in determining substrate specificity.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christine Krauth, Marta Fedoryshyn, Christian Schleberger, Andriy Luzhetskyy, Andreas Bechthold,