Progress of the synthesis of condensed pyrazole derivatives (from 2010 to mid-2013)

•We summarize nearly all reported condensed pyrazoles from 2010 to mid-2013.•The bioactivities of each kind of compound are briefly introduced.•The synthetic methods of each kind of compounds are figured out and compared.

Condensed pyrazole derivatives are important heterocyclic compounds due to their excellent biological activities and have been widely applied in pharmaceutical and agromedical fields. In recent years, numerous condensed pyrazole derivatives have been synthesized and advanced to clinic studies with various biological activities. In this review, we summarized the reported synthesis methods of condensed pyrazole derivatives from 2010 until now. All compounds are divided into three parts according to the rings connected to pyrazole-ring, i.e. [5, 5], [5,F 6], and [5, 7]-condensed pyrazole derivatives. The biological activities and applications in pharmaceutical fields are briefly introduced to offer an orientation for the design and synthesis of condensed pyrazole derivatives with good biological activities.

Graphical abstractThis review briefly introduces the bioactivities and summarizes the synthetic methodology of condensed pyrazole derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slide