Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine

•Recent advances on quinoxalines were discussed.•Roles as bioactive compounds were documented.•Relevant binding and SAR studies were expatiated.•Recognition as pathfinders in drug design was described.

Quinoxalines belong to a class of excellent heterocyclic scaffolds owing to their wide biological properties and diverse therapeutic applications in medicinal research. They are complementary in shapes and charges to numerous biomolecules they interact with, thereby resulting in increased binding affinity. The pharmacokinetic properties of drugs bearing quinoxaline cores have shown them to be relatively easy to administer either as intramuscular solutions, oral capsules or rectal suppositories. This work deals with recent advances in the synthesis and pharmacological diversities of quinoxaline motifs which might pave ways for novel drugs development.

Graphical abstractRecent advances in the synthesis and diverse biological activities of quinoxaline derivatives is herein reported making them resourceful tools in drug design and excellent pathfinders in therapeutic medicine.Figure optionsDownload full-size imageDownload as PowerPoint slide