Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities

•Norfloxacin derivatives including 1,3-thiazol(idinon)e, 1,3,4-oxadiazole or 1,2,4-triazole moiety have been synthesized.•Some of the synthesized compounds display excellent antimicrobial activity.•One compound have been found to possess antiurease activity.

Norfloxacin was converted to 7-(4-amino-2-fluorophenyl)piperazin derivative (2) via the formation of nitro compound. The synthesis of the norfloxacin derivatives containing 1,3-thiazole or 1,3-thiazolidin moiety was performed from the reaction of 4-chlorophenacylbromide or ethyl bromoacetate with compounds 4–7 obtained starting from 2. 3-Fluoro-4-[4-(2-methoxyphenyl)piperazin-1-yl]aniline (14), 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol (18) and {[4-(2-methoxy phenyl)piperazin-1-yl]methyl}-1,3,4-oxadiazol-2-thiol (19) were obtained starting from 1-(2-methoxyphenyl)piperazine by several steps. The treatment of hydrazide (16) with several aldehydes afforded N′-[(2-hydroxyphenyl)methylen]- (20), N′-[(3-hydroxy-4-methoxy phenyl)methylen]- (21) or N′-[1H-indol-3-ylmethylene]-2-[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide (22). Then, compounds 14, 18, 19 and 22 were condensed with 7-[4-(chloroacetyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (3) that was obtained from norfloxacine.All newly synthesized compounds were screened for their antimicrobial activities and some of them exhibited excellent activity. Moreover, one compound was found to have antiurease activity.

Graphical abstractMicrowave assisted synthesis of some norfloxacin derivatives containing different heterocyclic moieties was performed. Some of the compounds exhibited excellent antimicrobial activity. Moreover, one compound was found to have antiurease activity.Figure optionsDownload full-size imageDownload as PowerPoint slide