Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections

•We have synthesized newer series of quinolone derivatives substituted with hydrazine group and sulfonamide group.•The MIC of all these compounds has been studied and data were compared with norfloxacin and ciprofloxacin.•MIC data reveals that all the synthesized compounds exhibited good antibacterial activity in vitro.

We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a–e) and sulfonamide group (7a–e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro.

Graphical abstractCompounds (7a–e) are synthesized and their MIC data shows that all the synthesized compounds exhibited good antibacterial activity in vitro.Figure optionsDownload full-size imageDownload as PowerPoint slide