| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1392789 | European Journal of Medicinal Chemistry | 2012 | 9 Pages |
Abstract
As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Rigid analogues and isosteres of nicotinamide have been synthesized. ► Obtained compounds were tested to evaluate their cellular effects and sirtuin inhibition. ► The 3-triazolylpyridine inhibits selectively Sirt3 over Sirt1 and Sirt2.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ubaldina Galli, Ornella Mesenzani, Camilla Coppo, Giovanni Sorba, Pier Luigi Canonico, Gian Cesare Tron, Armando A. Genazzani,