Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents

Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.

Graphical abstractSome novel thienopyrimidine and fused thienopyrimidine derivatives with promising anti-inflammatory activity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis and anti-inflammatory activity of novel thienopyrimidines. ► Some compounds exhibited good anti-inflammatory activity relative to diclofenac Na. ► Compounds 4, 9, 10 and 13 were found to have the highest anti-inflammatory activity.