| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1392830 | European Journal of Medicinal Chemistry | 2012 | 8 Pages |
A series of 5-bromo-2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)pyrimidine were prepared under conventional heating as well as microwave reaction condition. The newly synthesized compounds were characterized on the basis of elemental, spectral and single crystal X-ray studies. These new compounds were screened for their antioxidant, anti-inflammatory and analgesic activities. Some of these compounds exhibited potent biological activities compared to the standard drug.
Graphical abstractA novel series of pyrazolines were synthesized under MW and evaluated for varies biological activities. Few compounds displayed excellent pharmacological property.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Microwave mediated synthesis of novel pyrazolines was achieved. ► Formation of pyrazoline was confirmed based on XRD studies. ► Results of antioxidant studies are highly encouraging. ► Few compounds displayed excellent anti-inflammatory and analgesic activity.
