| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1392882 | European Journal of Medicinal Chemistry | 2012 | 7 Pages |
A series of 6-bromo-2-ethyl-3-(substitutedbenzo[d]thiazol-2-yl)quinazolin-4(3H)-one 3 (a–j) were synthesized using appropriate synthetic route and evaluated experimentally by the Maximal Electro Shock (MES) and the PTZ-induced seizure methods. Among the tested compounds, 3-(benzo[d]thiazol-2-yl)-6-bromo-2-ethylquinazolin-4(3H)-one (3a) has shown significant activity against tonic seizure by the MES model and 6-bromo-2-ethyl-3-(6-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one (3h) against clonic seizure by PTZ-induced seizure model. Not one of the selected compounds demonstrated any sign of neurotoxicity and hepatotoxicity.
Graphical abstractIn the present study synthesis and anticonvulsant activity of novel quinazolino–benzothiazoles were evaluated.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis and anticonvulsant evaluation of 6-bromo-2-ethyl-3-(substitutedbenzo[d]thiazol-2-yl) quinazolin-4(3H)-one 3(a–j). ► Characterized by IR, 1H NMR, 13C NMR, FAB MASS technique. ► The title compound 3a and 3h shown promising anticonvulsant activity.
