Synthesis, anti-Candida activity, and cytotoxicity of new (4-(4-iodophenyl)thiazol-2-yl)hydrazine derivatives

Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.

Graphical abstractA new series of [4-(4′-iodo-phenyl)thiazol-2-yl]hydrazine derivatives were synthesized and assayed for in vitro anti-Candida, association with azoles, and cytotoxicity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis and antifungal activity of a new series of 2,4-disubstituted-thiazoles. ► New derivatives represent lead compounds for the development of anti-Candida agents. ► They could be used in association with azoles to enhance their antifungal activity. ► The most active derivatives displayed a lower cytotoxicity than clotrimazole.