| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1392903 | European Journal of Medicinal Chemistry | 2012 | 8 Pages |
Abstract
⺠New anti-TB compounds containing isocyanurate fragment have been synthesized. ⺠These compounds are potential inhibitors of β-ketoacyl synthase in mycobacteria. ⺠They have good activity against M. Tuberculosis (MIC 0.05-25 μg/mL). ⺠These compounds are nontoxic and highly species-specific. ⺠The efficacy varies with alkyl spacer length and combination of functional groups.
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Organic Chemistry
Authors
M.M. Shulaeva, S.G. Fattakhov, L.F. Saifina, R.V. Chestnova, R.Sh. Valijev, D.N. Mingaleev, A.D. Voloshina, V.S. Reznik,