Antiproliferative activity against human non-small cell lung cancer of two O-alkyl-diglycosylglycerols from the marine sponges Myrmekioderma dendyi and Trikentrion laeve

Glycolipids of Myrmekioderma sponges contain Myrmekiosides, a new family of glycolipids with a unique structure of mono-O-alkyl-diglycosylglycerols. This report deals with the identification and biological activity of the new Myrmekioside E from Myrmekioderma dendyi. Its structure has been elucidated from spectroscopic data and chemical degradation studies. It contained a glycerol backbone linked to xylose and N-acetylglucosamine, and an alkyl long-chain with a terminal alcohol group. A related glycolipid, Trikentroside, known in the sponge Trikentrion laeve, was subjected to a comparative biological evaluation. Both glycolipids inhibit proliferation of two human non-small cell lung cancer cell lines (NSCLC-N6 and A549).

Graphical abstractMyrmekioside E, a new mono-O-alkyl-diglycosylglycerol of a glycolipid series found in Myrmekioderma sponges, and the rare related Trikentroside from Trikentrion laeve, inhibit proliferation of two human cancer cell lines Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► O-alkylglycosylglycerols occurred in the sponges Trikentrion and Myrmekioderma. ► A new O-alkyl-diglycosylglycerol, Myrmekioside E, was isolated and characterized. ► These ether-linked glycolipids inhibit proliferation of human lung cancer cell lines.