| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393060 | European Journal of Medicinal Chemistry | 2011 | 5 Pages |
The polyester- and poly(ester-carbonate)-paclitaxel conjugates with low molecular weight were synthesized using dicyclohexylcarbodiimide (DCC) and dimethylaminopyridine (DMAP) as catalysts. Polymeric matrices were obtained by ring-opening polymerization of ɛ-caprolactone (CL), rac-lactide (rac-LA), l-lactide (LLA) and trimethylene carbonate (TMC). The macromolecular conjugates were characterized by using spectroscopic techniques, such as 1H, 13C NMR and FTIR. The degree of degradation of polyester- and poly(ester-carbonate)-paclitaxel conjugates was tested in vitro under different conditions. The preliminary results of drug release were discussed.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The novel macromolecular conjugates of paclitaxel (PACL) were obtained. ► Polymeric matrices were obtained by ring-opening polymerization of cyclic monomers. ► The poly(ester-carbonate) conjugates are interesting materials for the controlled release of PACL.
