| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393067 | European Journal of Medicinal Chemistry | 2011 | 6 Pages |
The synthesis of some novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described. All the sulphonophanes exhibit good antibacterial and antifungal activity against five bacterial strains Bacillus subtilis, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus vulgaris and human pathogenic fungus Candida albicans.
Graphical abstractThe synthesis and antimicrobial activity of novel imidazole-based dicationic sulfonophanes incorporating various spacer units is described.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Dicationic sulphonophanes is not known in the literature. ► Antimicrobial activity was enhanced due to the presence of sulphone and imidazole. ► All the antimicrobial agents prepared by simple reaction methodology, mild reaction conditions and low cost reagents. ► Sulphonophane 1 show very good antimicrobial activity against B. subtillis, S. aureus, P. vulgaris and C. albicans. ► Sulphonophane 5 show excellent antibacterial activity against V. Cholerae when compared with standard Ciprofloxacin.
