Molecular properties prediction, synthesis and antimicrobial activity of some newer oxadiazole derivatives

Twenty eight oxadiazole analogues (AB1-AB28) were subjected to molecular properties prediction. Out of which sixteen (AB1-AB2), (AB5-AB9), (AB12-AB16), (AB18-AB21) were chosen on the basis of Lipinski “Rule of Five” (Ro5) for the synthesis and antimicrobial screening as oral bioavailable drugs/leads. Compounds (AB13, AB20) having maximum drug-likeness model score were found to have good results against bacterial and fungal strains.