| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393139 | European Journal of Medicinal Chemistry | 2010 | 7 Pages |
Our continuing effort of searching bioactive substances from the Formosan soft coral Cladiella australis has led to the isolation of a bioactive substance austrasulfone (1), which possesses significant neuroprotective activities. A straightforward synthesis of 1 was achieved by a two-step reaction sequence. Dihydroaustrasulfone alcohol (3), the synthetic precursor of 1, not only exhibited in vitro anti-inflammatory activity, but also showed potent therapeutic ability in the treatment of neuropathic pain, atherosclerosis, and multiple sclerosis in rats.
Graphical abstractIsolation, activity, and synthesis of a new soft coral metabolite, austrasulfone (1), were described. Its synthetic intermediate, dihydroaustrasulfone alcohol (3), also exhibited promising in vitro and in vivo anti-inflammatory activity.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► A neuroprotective agent, austrasulfone (1), has been isolated from marine soft coral Cladiella australis. ► A straightforward synthesis of 1 was achieved by a two-step reaction sequence. ► Its synthetic intermediate, dihydroaustrasulfone alcohol (3), not only exhibited in vitro anti-inflammatory activity, but also showed potent therapeutic ability in the treatment of neuropathic pain, atherosclerosis, and multiple sclerosis in rats.
