Efficient synthesis of (6-deoxy-glycopyranosid-6-yl) sulfone derivatives and their effect on Ca2+-ATPase

Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes.

Graphical abstractConvenient synthesis of a series of novel (6-deoxygly-copyranosid-6-yl) sulfone derivatives and their bioevaluation against Ca2+-ATPase is reported. Yields were excellent in every case.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights►Synthesis of a series of novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives has been achieved using a general synthetic strategy. Yields were excellent in every case. The synthetic compounds were evaluated for their biological potential against Ca2+-ATPase, an important enzyme involves in tranporting Ca2+ across the cell membranes. ► Novel (6-deoxy-glycopyranosid-6-yl) sulfone derivatives have been synthesized. ► A high yielding general synthetic strategy has been used. ► The synthetic compounds were evaluated against Ca2+-ATPase. ► Compounds showed stimulatory effects on Mg2+ independent Ca2+-ATPase.