Article ID Journal Published Year Pages File Type
1393152 European Journal of Medicinal Chemistry 2010 6 Pages PDF
Abstract

In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in μM. The compounds were non-cytotoxic and exhibited an important activity (12.6 μM). The appreciable activity of these compounds can be considered an important finding for the rational design of new leads for anti-TB compounds.

Graphical abstractSeveral new mefloquine-oxazolidine derivatives have been synthesized and evaluated as antituberculosis agents. The compounds displayed substantial activities and high cell viability.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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