Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1393170 | European Journal of Medicinal Chemistry | 2010 | 8 Pages |
Abstract
A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Li Shen, Xiaochun Yang, Bo Yang, Qiaojun He, Yongzhou Hu,