| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1393182 | European Journal of Medicinal Chemistry | 2010 | 8 Pages |
Abstract
The novel glycosyl saccharide derivative, (d-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50 = 1.94 × 10−8 (LC50 = 2.76 × 10−8 for cisplatin) and so distinctly better than free ligand and other complexes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M.P. Sathisha, Srinivasa Budagumpi, Naveen V. Kulkarni, Gurunath S. Kurdekar, V.K. Revankar, K.S.R. Pai,