Article ID Journal Published Year Pages File Type
1393195 European Journal of Medicinal Chemistry 2010 9 Pages PDF
Abstract

A series of novel ferrocenyl pyrazolo[1,5–a]pyrazin-4(5H)-one derivatives was synthesized and characterized by 1H NMR, 13C NMR, IR, HRMS and X-ray diffraction analysis. Preliminary evaluation of biological applications showed that the compounds 6c and 6f inhibit the growth of A549 cells in dosage-dependent manners through cell cycle arrest.

Graphical abstractNovel ferrocenyl pyrazolo[1,5–a]pyrazin-4(5H)-one derivatives were synthesized and characterized by spectroscopy and X-ray diffraction analysis. The compounds 6c and 6f were found to inhibit the growth of A549 cells through cell cycle arrest.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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