Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1393195 | European Journal of Medicinal Chemistry | 2010 | 9 Pages |
Abstract
A series of novel ferrocenyl pyrazolo[1,5–a]pyrazin-4(5H)-one derivatives was synthesized and characterized by 1H NMR, 13C NMR, IR, HRMS and X-ray diffraction analysis. Preliminary evaluation of biological applications showed that the compounds 6c and 6f inhibit the growth of A549 cells in dosage-dependent manners through cell cycle arrest.
Graphical abstractNovel ferrocenyl pyrazolo[1,5–a]pyrazin-4(5H)-one derivatives were synthesized and characterized by spectroscopy and X-ray diffraction analysis. The compounds 6c and 6f were found to inhibit the growth of A549 cells through cell cycle arrest.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yong-Sheng Xie, Hong-Ling Zhao, Hua Su, Bao-Xiang Zhao, Jin-Ting Liu, Ji-Kun Li, Hong-Shui Lv, Bai-Shan Wang, Dong-Soo Shin, Jun-Ying Miao,