Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1393197 | European Journal of Medicinal Chemistry | 2010 | 9 Pages |
Abstract
The drug resistance mechanisms of three mutants to an inhibitor GRL-98065 are explained by using binding free energies and structural analysis. The results agree well with the experimental results.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Guo-Dong Hu, Tong Zhu, Shao-Long Zhang, Dunyou Wang, Qing-Gang Zhang,