Article ID Journal Published Year Pages File Type
1393265 European Journal of Medicinal Chemistry 2009 5 Pages PDF
Abstract

The reactions between [Pd(C2,N-dmba)(μ-X)]2 (dmba = N,N-dimethylbenzylamine; X = Cl, Br) and thiourea (tu) in the 1:2 molar ratio at room temperature resulted in the mononuclear compounds [Pd(C2,N-dmba)(Cl)(tu)] (1) and [Pd(C2,N-dmba)(Br)(tu)] (2), which were characterized by elemental analyses and infrared (IR), 1H- and 13C{1H} NMR spectroscopies. The crystal and molecular structures of 2 were determined by single-crystal X-ray diffraction. In vitro cytotoxicity assays of the compounds 1, 2, tu, dmba and cisplatin were carried out using two murine tumor cell lines, namely mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). The compounds 1, 2, tu and dmba were also tested against Mycobacterium tuberculosis and their MIC values were determined.

Graphical abstract The antitumor and antitubercular activities of the compounds [Pd(C2,N-dmba)(X)(tu)] {dmba = N,N-dimethylbenzylamine; X = Cl (1), Br (2)} were evaluated in this work.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
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